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Biomedical Research Instruments

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Neuroscience Research Instruments for Mice and Rats

Optical imaging, behavior, physiology monitoring and virtual reality instruments for neuroscience research in head-fixed and freely moving mice and rats. Each instrument works on its own and synchronizes with the rest of your rig over TTL.

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LabeoTech optical imaging system set up for widefield cortical imaging in a mouse
Imaging & optogenetics

Widefield Cortical Imaging

Widefield intrinsic, fluorescence and speckle imaging, with optogenetic stimulation through the same optical path.

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Head-fixed mouse in a virtual reality setup with a compact headset and spherical treadmill
Virtual reality

Virtual Reality for Mice

Head-fixed mice navigate virtual corridors and mazes on a spherical treadmill, for spatial navigation and decision-making tasks.

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Sensory stimulation

Stimulation Devices

Air puff, mechanical whisker, olfactory, Ganzfeld, flash and acoustic stimulators, triggered by TTL.

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Optical Imaging, Behavior and Physiology Equipment

Each family page lists the devices with their specifications and compatible equipment.

Low friction rodent driven belt treadmill for head-fixed locomotion studies

Behavioral Research

Head fixation, treadmills and running wheels, whisker, olfactory, acoustic and visual stimulators, reward and decision devices, infrared cameras and automated home cages.

Behavioral research
Small Animal Monitoring System with tablet display and integrated ear and tooth bars

Physiology Monitoring

ECG, respiration, heart and breath rate, core temperature with active warming, SpO2, blood pressure and exhaled CO2, plus cardiac and respiratory gating for imaging.

Physiology monitoring
Complete virtual reality setup for head-fixed mice: spherical treadmill, reward and stimulation devices, display enclosure and control computer

Virtual Reality

Headset or dual display, spherical treadmill, reinforcement devices and VRLab Suite software as one integrated system for head-fixed mice.

Virtual reality

Prices and specifications are in the store. For a configuration quote, an institutional purchase order, or a question about compatibility with your existing rig, contact us.

From the blog

Methods, Case Studies and Protocols

Write-ups on widefield calcium imaging, intrinsic optical signal imaging, eye tracking and behavioral analysis, with data from labs using these instruments.

Read the blog Also: Publications · Protocols & white papers · Downloads

Synchronizing Imaging, Behavior and Physiology

Behavioral experiments rarely use a single device. Ours are built to be combined, mechanically, electrically and in software, so an imaging run, a behavioral task and a physiological recording stay on the same clock instead of being aligned afterwards.

  • Run each instrument the way that suits your lab: by TTL, from the instrument's own software, from PsychoPy, from Maestro, or from your own Python scripts
  • A PsychoPy plugin ships with the devices, so existing paradigms run without extra code
  • TTL synchronization across stimulation, imaging, behavior and physiology
  • Cardiac and respiratory gating locks acquisition to the same point in every cycle
  • Optogenetic stimulation on the OiS200 runs through the imaging path, so stimulated and imaged regions share a coordinate frame

Recorded on the Same Clock

Stimulus onset, frame acquisition, licks and heart rate all timestamped against each other, not reconciled from separate files after the session.

Fits Existing Rigs

Instruments are designed to drop into the rig you already have.

Software and Services

Acquisition and control software for the instruments, analysis of imaging and behavioral video data, imaging studies run in our lab, and custom devices.

Software

Maestro trial structure: a state diagram alternating whisker and air puff stimulation with an inter-stimulus interval

MaestroExperiment control software

Set the trial structure (stimulus, response window, reward, inter-trial interval) and Maestro runs every device in the rig on that sequence: stimulators, reward delivery, cameras and acquisition.

About Maestro
Mouse-eye view of a Y-maze virtual reality environment in VRLab Suite, with striped wall cues

VRLab SuiteVR software for mice

Ready-to-run virtual reality experiments with moving objects, trigger zones, TTL and audio outputs, and video synchronized to the session.

About VRLab Suite
Behavioral camera with infrared illumination on an adjustable post mount

Behavioral CameraVideo acquisition & real-time tracking

Record pupil, whiskers or paws under infrared, with frames triggered by your acquisition system and DeepLabCut tracking shown live (up to 100 fps). Acquisition software included at no cost.

About the camera

Services

Optical Imaging Data Analysis

Preprocessing, functional mapping and quantification of widefield and intrinsic optical signal datasets, including per-animal cortical maps for targeting electrophysiology or microinjections.

About the service

DeepLabCut Behavioral Tracking

Markerless tracking of limbs, whiskers, pupil and body posture from your video, delivered as coordinates and trained models you can rerun on new sessions yourself.

About the service

Preclinical Optical Imaging StudiesCRO service

Imaging studies run in our lab on your animal models: calcium and speckle imaging, fiber photometry, optogenetics, bioluminescence and fluorescence.

Discuss a study

Custom DevicesBuilt or adapted for your setup

Modified versions of our instruments, or new devices designed and built for a specific experiment: mechanics, electronics and control software.

Describe your setup
Fits the rest of your setup Two-photon imaging Electrophysiology Ultrasound PsychoPy TTL & BNC sync CSV, MATLAB, Excel, LabChart

Frequently Asked Questions

What species are these instruments designed for?

Primarily mice and rats. Physiology monitoring covers mice, neonatal rats and adult rats depending on the model, and the ECG & respiration gating system is additionally specified for guinea pigs and marmosets. The virtual reality and head fixation systems are built around head-fixed mice.

Can I use one instrument on its own, or do I need the whole system?

Every instrument works on its own. They are designed to be combined, not sold as an all-or-nothing platform: most labs start with one device and add to it. If you already have an imaging or electrophysiology rig, these are built to drop into it.

How do the devices synchronize with my existing acquisition?

Through TTL and BNC lines, and through a PsychoPy plugin that ships with the devices. Stimulators, cameras and acquisition can be triggered from Maestro or from your own software, so stimulus onset and frame timing share a timestamp rather than being aligned afterwards.

Can I see the instruments used in published research?

Yes. Our publications page lists peer-reviewed work featuring LabeoTech systems, and the blog covers specific methods and case studies in more detail.

Tell Us What Your Experiment Needs

Describe the preparation, the species and what you need to measure. We'll come back with the instruments that cover it, and what is needed around them.

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